Research

Recent News

  • Alert PyschNews(2017) Adjunctive Ketamine Appears to Reduce Suicidal Thoughts in Depressed Patients for Up to Six Weeks.
  • CurrentPsychiatry.com (2016) The Future of Ketamine in Psychiatry.
  • Psychology Today (2016) A New Medication on the Horizon for Depression.
  • Neurology Advisor (2016) Ketamine May Be Effective in Major Depression.
  • Psychiatry Advisor (2016) Ketamine May Provide Lasting Relief From Depression.
  • Economist.com (2016) Novel drugs for depression.
  • PRNewswire (2016) New Study Shows Ketamine May Regenerate Brain Cells, Relieving Depression with Lasting Benefit.
  • New York Magazine (2016) What It’s Like to Have Your Severe Depression Treated With a Hallucinogenic Drug.
  • J&J Press Release (2016) Esketamine Receives Breakthrough Therapy Designation from U.S. Food and Drug Administration for Major Depressive Disorder with Imminent Risk for Suicide.
  • CNN.com (2016) Party Drug Ketamine Closer to Approval for Depression.
  • Nature.com (2016) How Club Drug Ketamine Fights Depression.
  • NPR.com (2015) Depression Treatments Inspired By Club Drug Move Ahead In Tests.
  • Bloomberg (2015) The Ketamine Cure.
  • NPR (2015) Club Drug Ketamine Gains Traction As A Treatment For Depression.
  • Nature.com (2015) Rave drug holds promise for treating depression fast.
  • VICE News (2015) I Used Ketamine to Treat My Depression.
  • NY Times (2014) Special K, a Hallucinogen, Raises Hopes and Concerns as a Treatment for Depression.
  • Scientific American (2013) Is Ketamine the Next Big Depression Drug?
  • Time (2013) ‘Club Drug’ Ketamine Lifts Depression in Hours.
  • NPR.com (2012) Ketamine Relieves Depression By Restoring Brain Connections.
  • PsychiatricNews.com (2012) Ketamine-Induced Optimism: New Hope for the Development of Rapid-Acting Antidepressants.
  • TheAtlantic.com (2012) ‘The Biggest Breakthrough in Depression Research’ in 50 Years Is … Ketamine?
  • National Institutes of Mental Health (2010) Rapid Antidepressant Works by Boosting Brain’s Connections

Research & News

Literature on Therapy for Depression

  • Arunogiri S, Keks NA, Hope J. Should ketamine be used for the clinical treatment of depression? Australas Psychiatry. Aug 2016;24(4):381-384.
  • Bobo WV, Voort JL, Croarkin PE, Leung JG, Tye SJ, Frye MA. Ketamine for Treatment-Resistant Unipolar and Bipolar Major Depression: Critical Review and Implications for Clinical Practice. Depress Anxiety. Apr 6 2016.
  • Caddy C, Amit BH, McCloud TL, et al. Ketamine and other glutamate receptor modulators for depression in adults. Cochrane Database Syst Rev. 2015(9):CD011612.
  • Fond G, Loundou A, Rabu C, et al. Ketamine administration in depressive disorders: a systematic review and meta-analysis. Psychopharmacology (Berl). Sep 2014;231(18):3663-3676.
  • Hasselmann HW. Ketamine as antidepressant? Current state and future perspectives. Curr Neuropharmacol. Jan 2014;12(1):57-70.
  • Henderson TA. Practical application of the neuroregenerative properties of ketamine: real world treatment experience. Neural Regen Res. Feb 2016;11(2):195-200.
  • Lapidus KA, Levitch CF, Perez AM, et al. A randomized controlled trial of intranasal ketamine in major depressive disorder. Biol Psychiatry. Dec 15 2014;76(12):970-976.
  • Messer M, Hailer I. Maintenance ketamine treatment produces long-term recovery from depression. Primary Psychiatry. May 21, 2013.
  • McGirr A, Berlim MT, Bond DJ, Fleck MP, Yatham LN, Lam RW. A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes. Psychol Med. Mar 2015;45(4):693-704.
  • Murrough JW, Iosifescu DV, Chang LC, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. Oct 2013;170(10):1134-1142.
  • Newport DJ, Carpenter LL, McDonald WM, et al. Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression. Am J Psychiatry. Oct 2015;172(10):950-966.
  • Niciu MJ, Luckenbaugh DA, Ionescu DF, et al. Clinical predictors of ketamine response in treatment-resistant major depression. J Clin Psychiatry. May 2014;75(5):e417-423.
  • Rasmussen KG, Lineberry TW, Galardy CW, et al. Serial infusions of low-dose ketamine for major depression. J Psychopharmacol. May 2013;27(5):444-450.
  • Singh JB, Fedgchin M, Daly EJ, et al. A double-blind, randomized, placebo-controlled, dose-frequency study of intravenous ketamine in patients with treatment-resistant depression. Am J Psychiatry. Apr 8 2016:appiajp201616010037.
  • Solovitch S. Onetime party drug hailed as miracle for treating severe depression. The Washington Post. 2016.
  • Stiles, L. Ketamine may provide lasting relief from depression. Psychiatry Advisor. March, 24 2016.

Literature on Therapy for Post Traumatic Stress Disorder

  • Cassels, C. Ketamine: New potential as rapid PTSD treatment not just for depression anymore? Medscape Medical News. April 17 2014. (Free Medscape login required)
  • Canadian Agency for Drugs and Technologies in Health. Intravenous Ketamine for the Treatment of Mental Health Disorders: A Review of Clinical Effectiveness and Guidelines. Ottawa (ON). Aug 20 2014.
  • Feder A, et al. Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder, JAMA Psychiatry. 2014;71(6):681-688.
  • Womble, A. Effects of Ketamine on Major Depressive Disorder in a Patient with Posttraumatic Stress Disorder, AANA J. 2013;81(2):118-119.

Literature on Therapy for Chronic Pain

  • Birklein F, O’Neill D, Schlereth T. Complex regional pain syndrome: An optimistic perspective. Neurology. Jan 6 2015;84(1):89-96.
  • Connolly SB, Prager JP, Harden RN. A systematic review of ketamine for complex regional pain syndrome. Pain Med. May 2015;16(5):943-969.
  • Kim M, Cho S, Lee JH. The effects of long-term ketamine treatment on cognitive function in complex regional pain syndrome: A preliminary study. Pain Med. Aug 2016;17(8):1447-1451.
  • Niesters M, Martini C, Dahan A. Ketamine for chronic pain: risks and benefits. Br J Clin Pharmacol. Feb 2014;77(2):357-367.
  • O’Brien SL, Pangarkar S, Prager J. The use of ketamine in neuropathic pain. Curr Phys Med Rehabil Rep. 2014;2(2):128-145.
  • Puchalski P, Zyluk A. Results of the treatment of chronic, refractory CRPS with ketamine infusions: a preliminary report. Handchir Mikrochir Plast Chir. Jun 2016;48(3):143-147.
  • Sheehy KA, Muller EA, Lippold C, Nouraie M, Finkel JC, Quezado ZM. Subanesthetic ketamine infusions for the treatment of children and adolescents with chronic pain: a longitudinal study. BMC Pediatr. 2015;15:198.
  • Xu J, Yang J, Lin P, Rosenquist E, Cheng J. Intravenous therapies for complex regional pain syndrome: A systematic review. Anesth Analg. Mar 2016;122(3):843-856.

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We promised to take care and delivered

  • I could not be happier with the results of my treatment. Every aspect of my depression, from the difficulty thinking to anxiety, to the just plain lack of joy in what should be everyday human pleasures has drastically improved.
    J.W
  • The sense of wellbeing sneaked up on me. Instead of coming directly from the infusions like I expected, it came from doing all these new things that ketamine has freed me to do.
    R.S
  • It was life changing. I had suffered from depression for 35 years. I achieved remission within eight hours.
    D.H
  • Ketamine is truly a life-changing treatment. I now have a new lease on life!
    Anonymous
  • I did an initial series of 6 treatments in a two week period. I have never felt better in years! I would recommend this treatment to anyone struggling with depression.
    K.T